The ApoE genetic marker (Apolipoprotein E) is one gene responsible for interpreting the likelihood for an individual to develop Alzheimer's disease.
Genetic markers are DNA sequences that can connect inherited diseases to specific genes. In the brain, ApoE is a protein that plays a role in removing harmful plaques that accumulate around nerve cells. These plaques are characteristic of Alzheimer's Disease and are made up of damaged proteins known as amyloid-ß (Aß), which cluster together to form toxic deposits. There are three types of ApoE proteins: E2, E3, and E4. Each person inherits two of these proteins, one from each parent.
Tect code:
9113
Sample type:
Cheek Buccal Swab
Preparation:
You do not need to do anything special to prepare for the sample collection. Fasting is not required for this test.
Individuals with the E2 allele have the lower risk of developing Alzheimer’s Disease, as this variant of the protein is the most effective at clearing Aß plaques.
People with the E3 allele do not have an elevated risk of developing Alzheimer’s Disease.
People with the E4 allele have a greatly increased risk of developing Alzheimer’s Disease because this version of the protein is less effective at clearing Aß plaques.